Do not cut, break, crush, chew, or make an effort to dissolve OxyContin as this can impair the controlled-launch shipping method and should lead to a most likely fatal dose of oxycodone. OxyContin may well induce sedation which can impair your reaction skills and affect your capacity to drive or function equipment.
Shop at home temperature faraway from light-weight and dampness. Never retail store in the bathroom. Preserve all medications far from youngsters and pets. See also Warning portion.
The concomitant usage of OXYCONTIN and CYP3A4 inducers can minimize the plasma focus of oxycodone [see CLINICAL PHARMACOLOGY], causing reduced efficacy or onset of a withdrawal syndrome in individuals who have produced physical dependence to oxycodone [see WARNINGS AND Safeguards].
Instruct people to swallow OXYCONTIN tablets complete; crushing, chewing, or dissolving OXYCONTIN tablets may cause swift launch and absorption of the likely fatal dose of oxycodone [see WARNINGS AND Safety measures].
Warn patients with the indicators of serotonin syndrome and to hunt professional medical consideration instantly if signs and symptoms create. Instruct clients to tell their healthcare service provider If they're taking, or decide to consider serotonergic medications [see DRUG INTERACTIONS].
Chances are you'll observe an vacant tablet shell in your stool. This is often harmless for the reason that Your whole body has by now absorbed the medicine.
Advise clients and caregivers not to boost opioid dosage devoid of first consulting a clinician. Recommend clients to seek clinical focus whenever they practical experience signs or symptoms of hyperalgesia, which includes worsening check here discomfort, elevated sensitivity to agony, or new ache [see WARNINGS AND Safety measures and ADVERSE REACTIONS].
residing in a family in which you can find little young children or someone that has abused Avenue or prescription medicines getting prescription or above-the-counter medicines, nutritional vitamins, or herbal dietary supplements. Taking OXYCONTIN with sure other medicines can result in serious Unwanted side effects that would bring on death.
Psychological dependence (addiction) is unlikely to happen when narcotics are employed for this objective. Bodily dependence might cause withdrawal side effects if treatment method is stopped abruptly. However, extreme withdrawal Unwanted side effects can commonly be prevented by steadily minimizing the dose over a time frame in advance of treatment is stopped fully. This medication is out there only under a restricted distribution method known as the Opioid Analgesic REMS (Possibility Evaluation and Mitigation System) application. This solution is obtainable in the following dosage forms:
On top of that, discontinuation of the concomitantly used cytochrome P450 3A4 inducer could enhance oxycodone plasma focus. People getting oxycodone and any CYP3A4 inhibitor or inducer need to be routinely monitored.
OXYCONTIN need to be prescribed only by Health care experts that are experienced about using prolonged-release/very long-performing opioids and the way to mitigate the related threats.
Tend not to flush medications down the toilet or pour them right into a drain Except if instructed to do so. Appropriately discard this item when it is actually expired or no longer wanted. For additional information, study here the Medication Tutorial, or speak to your pharmacist or regional waste disposal company.
Advise sufferers and caregivers that most likely fatal additive outcomes could occur if OXYCONTIN is applied with benzodiazepines or other CNS depressants, which includes Alcoholic beverages, instead of to work with these concomitantly unless supervised by a healthcare company [see WARNINGS AND Safety measures and DRUG INTERACTIONS].
The causal role of opioids from the scientific syndrome of hypogonadism is unknown because the various clinical, physical, Way of living, and psychological stressors that could affect gonadal hormone stages check here have not been sufficiently controlled for in experiments conducted thus far [see ADVERSE REACTIONS].